Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes
Identifieur interne : 008089 ( Main/Exploration ); précédent : 008088; suivant : 008090Tumor Lymphangiogenesis Predicts Melanoma Metastasis to Sentinel Lymph Nodes
Auteurs : Sam S. Dadras [États-Unis] ; Bernhard Lange-Asschenfeldt [États-Unis] ; Alona Muzikansky [États-Unis] ; Martin C. Mihm [États-Unis] ; Michael Detmar [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Cutaneous melanoma is a common and frequently lethal melanocytic neoplasm that can quickly metastasize to regional lymph nodes. Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.
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DOI: 10.1111/j.0303-6987.2005.320bd.x
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Currently, prognosis is determined by measuring tumor thickness but more reliable markers for metastatic spread are urgently needed. We investigated whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes (SLN). We quantified the extent of tumor lymphangiogenesis, as well as other factors, in excised primary tumors and in SLN biopsy samples from 45 patients with primary cutaneous melanoma. Primary melanomas from patients whose tumors had metastasized to the SLN, along with their metastastic foci, contained prominent hotspots of increased lymphatic vessel density, compared to non‐metastatic tumors. Multivariate risk analysis revealed that the lymphatic vascular area (LVA) of primary melanomas, an index of tumor lymphangiogenesis, was the most sensitive prognostic marker for SLN metastasis, and was even able to more accurately predict which tumors would become metastatic to SLN than measuring tumor thickness. The extent of tumor lymphangiogenesis is a highly sensitive (83%) and specific (89%) prognostic marker of lymph node metastasis. Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Dadras, Sam S" sort="Dadras, Sam S" uniqKey="Dadras S" first="Sam S." last="Dadras">Sam S. Dadras</name></region><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><name sortKey="Lange Sschenfeldt, Bernhard" sort="Lange Sschenfeldt, Bernhard" uniqKey="Lange Sschenfeldt B" first="Bernhard" last="Lange-Asschenfeldt">Bernhard Lange-Asschenfeldt</name><name sortKey="Mihm, Martin C" sort="Mihm, Martin C" uniqKey="Mihm M" first="Martin C." last="Mihm">Martin C. Mihm</name><name sortKey="Muzikansky, Alona" sort="Muzikansky, Alona" uniqKey="Muzikansky A" first="Alona" last="Muzikansky">Alona Muzikansky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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